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AS105

CAT: 0013-GTR19240093Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240093Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS105 (AS-105) is a highly potent, ATP-competitive CaMKII inhibitor, inhibits CaMKIIδ with IC50 of 8 nM, Ki of 3 nM. AS105 is also effective against autophosphorylated CaMKII (in contrast to the commonly used allosteric CaMKII-inhibitor KN-93) . In isolated atrial cardiomyocytes from human donors and ventricular myocytes from CaMKIIδC-overexpressing mice with heart failure, AS105 effectively reduced diastolic SR Ca2+ leak by 38% to 65% as measured by Ca2+-sparks or tetracaine-sensitive shift in [Ca2+]i. AS105 effectively reduced SR Ca2+-leak, thus improving SR Ca2+-accumulation and reducing cellular arrhythmogenic correlates, without negatively influencing excitation-contraction coupling.
CAS Number
1026029-18-4
Purity
>98%
Smiles
C1 (NCCN) C=C (C=CC=1) C1=NC (NC2C=CC=C (C=2) Cl) =NC=C1
Molecular Formula
C18H18CLN5
Molecular Weight
339.822021961212
Notes
For research use only.

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