THK5351

• UNSPSC Description:

  THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.

• Target Antigen:

  Tau Protein

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/THK5351.html

• Purity:

  98.94

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O[C@@H](COC1=CC=C2N=C(C3=CC=C(NC)N=C3)C=CC2=C1)CF

• Molecular Weight:

  327.35

• References & Citations:

  [1]Harada R, et al. 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J Nucl Med. 2016 Feb;57(2):208-14.|[2]Ishiki A, et al. Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy. Eur J Neurol. 2017 Jan;24(1):130-136.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 2

• CAS Number:

  1707147-26-9