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Progerinin

CAT: 0013-GTR19239724-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239724-02Size:5 mg
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Description
Progerinin (SLC-D011) is an orally bioavailable small molecule inhibitor of the progerin-lamin A interaction. It is used in HGPS research to ameliorate nuclear abnormalities and cellular senescence in both in vitro and in vivo models, facilitating the study of this premature aging syndrome.
CAS Number
2249696-72-6
Product Name Alternative
SLCD011, SLC-D011
Smiles
CC1 (C) OC=2C (=CC3=C (C2) OC (=O) C=C3) C[C@@H]1OC/C=C/C4=CC=CC=C4
Molecular Formula
C23H22O4
Molecular Weight
362.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Progerinin
CAS Number2249696-72-6
PubChem CID46220467
IUPAC Name(3S)-2,2-dimethyl-3-[(E)-3-phenylprop-2-enoxy]-3,4-dihydropyrano[3,2-g]chromen-8-one
Molecular FormulaC23H22O4
Molecular Weight362.4
XLogP4.6
Topological Polar Surface Area44.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity587
SMILES
CC1([C@H](CC2=C(O1)C=C3C(=C2)C=CC(=O)O3)OC/C=C/C4=CC=CC=C4)C
InChI
InChI=1S/C23H22O4/c1-23(2)21(25-12-6-9-16-7-4-3-5-8-16)14-18-13-17-10-11-22(24)26-19(17)15-20(18)27-23/h3-11,13,15,21H,12,14H2,1-2H3/b9-6+/t21-/m0/s1
InChIKey
KTTIANPTCWGYCN-JLXBBBJOSA-N
Chemical Structure
2D Structure
2D structure of Progerinin
CAS: 2249696-72-6
CID: 46220467
Formula: C23H22O4
MW: 362.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight362.4
XLogP34.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass362.15180918
Monoisotopic Mass362.15180918
Topological Polar Surface Area44.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity587
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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