PB2

• Description:

  PB2 is a tris (2-carboxyethyl) phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs[1].

• UNSPSC:

  12352005

• Target:

  Influenza Virus

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pb2.html

• Purity:

  99.84

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  [H-][B+3] ([P] (CCC (OC) =O) (C1=CC=CC=C1) C2=CC=CC=C2) ([H-]) [H-]

• Molecular Formula:

  C16H20BO2P

• Molecular Weight:

  286.11

• References & Citations:

  [1]Schlieve CR, et al. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells. Exp Eye Res. 2006;83 (5) :1252-1259.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  914940-24-2