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MeIm

CAT: 0013-GTR19239306-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239306-03Size:100 mg
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Description
MeIm (compound 7) is a PCSK9-targeting peptide mimetic with cholesterol-lowering activity, demonstrated by its ability to enhance LDL cellular uptake (EC50 = 6.04 μM) and inhibit the PCSK9-LDLR interaction (IC50 = 11.2 μM) . It serves as a valuable research tool for studying lipid metabolism and cardiovascular disease in both cellular and animal models.
CAS Number
2043947-71-1
Field of Research
Metabolism Research
Smiles
N=1C=C (C2=NC=C (C3=NC=C (C4=NC=C (C=5C=CC=CC5) N4C) N3C) N2C) N (C1) C
Molecular Formula
C22H22N8
Molecular Weight
398.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-Methyl-2-[3-methyl-2-(3-methylimidazol-4-yl)imidazol-4-yl]-5-(1-methyl-5-phenylimidazol-2-yl)imidazole
CAS Number2043947-71-1
PubChem CID145969348
IUPAC Name1-methyl-2-[3-methyl-2-(3-methylimidazol-4-yl)imidazol-4-yl]-5-(1-methyl-5-phenylimidazol-2-yl)imidazole
Molecular FormulaC22H22N8
Molecular Weight398.5
XLogP1
Topological Polar Surface Area71.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity583
SMILES
CN1C=NC=C1C2=NC=C(N2C)C3=NC=C(N3C)C4=NC=C(N4C)C5=CC=CC=C5
InChI
InChI=1S/C22H22N8/c1-27-14-23-10-17(27)20-25-12-19(29(20)3)22-26-13-18(30(22)4)21-24-11-16(28(21)2)15-8-6-5-7-9-15/h5-14H,1-4H3
InChIKey
JYKZQFAVSJPBQM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Methyl-2-[3-methyl-2-(3-methylimidazol-4-yl)imidazol-4-yl]-5-(1-methyl-5-phenylimidazol-2-yl)imidazole
CAS: 2043947-71-1
CID: 145969348
Formula: C22H22N8
MW: 398.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.5
XLogP31
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass398.19674274
Monoisotopic Mass398.19674274
Topological Polar Surface Area71.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity583
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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