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Z32439948

CAT: 0804-HY-162340Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162340Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells[1].
CAS Number
920845-86-9
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/z32439948.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC1=CNC2=C1C=CC=C2)C3=CC=C(OC)C(S(NCCC4=NC=CC=C4)(=O)=O)=C3
Molecular Formula
C25H26N4O4S
Molecular Weight
478.56
References & Citations
[1]Lu X, et al. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease. ACS Chem Neurosci. 2024 Mar 20;15 (6) :1135-1156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE

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CatalogName
T87656-01Z32439948

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