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YTR107

CAT: 0013-GTR19238205-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238205-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YTR107 is a small molecule radiosensitizer that targets nucleophosmin 1 (NPM1), disrupting its pentamerization. This action impairs NPM1 recruitment to DNA damage sites and inhibits double-strand break repair, thereby enhancing radiation-induced cell death in cancer research models, both in vitro and in vivo.
CAS Number
1207615-74-4
Smiles
N#CC1=CC=C (C=C1) CN2C=C (C=C3C (=O) NC (=O) NC3=O) C=4C=CC=CC42
Molecular Formula
C21H14N4O3
Molecular Weight
370.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-[[3-[(2,4,6-Trioxo-1,3-diazinan-5-ylidene)methyl]indol-1-yl]methyl]benzonitrile
CAS Number1207615-74-4
PubChem CID45102609
IUPAC Name4-[[3-[(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]indol-1-yl]methyl]benzonitrile
Molecular FormulaC21H14N4O3
Molecular Weight370.4
XLogP2.4
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity722
SMILES
C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)C#N)C=C4C(=O)NC(=O)NC4=O
InChI
InChI=1S/C21H14N4O3/c22-10-13-5-7-14(8-6-13)11-25-12-15(16-3-1-2-4-18(16)25)9-17-19(26)23-21(28)24-20(17)27/h1-9,12H,11H2,(H2,23,24,26,27,28)
InChIKey
UGGIKHBVNATJPW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[[3-[(2,4,6-Trioxo-1,3-diazinan-5-ylidene)methyl]indol-1-yl]methyl]benzonitrile
CAS: 1207615-74-4
CID: 45102609
Formula: C21H14N4O3
MW: 370.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight370.4
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass370.10659032
Monoisotopic Mass370.10659032
Topological Polar Surface Area104 Ų
Heavy Atom Count28
Formal Charge0
Complexity722
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T89140-01YTR107

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