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Quarfloxin

CAT: 0804-HY-14776-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14776-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].
CAS Number
865311-47-3
Product Name Alternative
CX-3543
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Quarfloxin.html
Purity
99.88
Solubility
H2O : 1 mg/mL (ultrasonic; adjust pH to 5 with 0.1 M HCl)
Smiles
O=C(C1=CN2C3=C(C(N4CC(C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
Molecular Formula
C35H33FN6O3
Molecular Weight
604.67
References & Citations
[1]Hald ØH, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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BA3967-10Quarfloxin
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A12380-50Quarfloxin (CX-3543) 50mg
A12380-5Quarfloxin (CX-3543) 5mg
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A12380-10Quarfloxin (CX-3543) 10mg
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