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F17464

CAT: 0013-GTR19236837Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236837Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
F17464 is a dopamine D3 receptor preferential antagonist exhibiting high affinity for human dopamine receptor subtype 3 (hD3) (Ki=0.17 nM) and 5-HT1a (Ki=0.16 nM) and a >50 fold lower affinity for the human dopamine receptor subtype 2 short and long form (hD2s/l) (Ki=8.9 and 12.1 nM, respectively) . F17464 is a D3 receptor antagonist, 5-HT1a receptor partial agonist. F17464 blocks ketamine induced morphological changes, an effect D3 receptor mediated, in human dopaminergic neurons. F17464 increases dopamine release in the rat prefrontal cortex and mouse lateral forebrain-dorsal striatum and seems to reduce the effect of MK801 on % c-fos mRNA medium expressing neurons in cortical and subcortical regions. F17464 also rescues valproate induced impairment in a rat social interaction model of autism, with dose range 0.32-2.5 mg/kg i.p. in both rats and mice
CAS Number
1268334-26-4
Purity
>98%
Molecular Formula
C25H30ClN3O6S
Molecular Weight
536.04
Notes
For research use only.

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