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ALK4290 dihydrochloride

CAT: 0013-GTR19235688-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19235688-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALK4290 dihydrochloride is a potent, orally bioavailable CCR3 antagonist with a Ki of 3.2 nM against human CCR3. It is utilized in research models for neovascular age-related macular degeneration and Parkinson's disease, demonstrating efficacy in both in vitro and in vivo experimental settings.
CAS Number
1372127-19-9
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Smiles
CN (C) C (C1=CC (C) =NC (NC ([C@@H]2N (C3CCN (CC3) CC4=CC (C) =C (C=C4) Cl) C (CC2) =O) =O) =C1) =O.Cl.Cl
Molecular Formula
C27H36Cl3N5O3
Molecular Weight
584.97
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Lazucirnon hydrochloride
CAS Number1372127-19-9
PubChem CID71767528
IUPAC Name2-[[(2R)-1-[1-[(4-chloro-3-methylphenyl)methyl]piperidin-4-yl]-5-oxopyrrolidine-2-carbonyl]amino]-N,N,6-trimethylpyridine-4-carboxamide;dihydrochloride
Molecular FormulaC27H36Cl3N5O3
Molecular Weight585.0
Topological Polar Surface Area85.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity802
SMILES
CC1=CC(=CC(=N1)NC(=O)[C@H]2CCC(=O)N2C3CCN(CC3)CC4=CC(=C(C=C4)Cl)C)C(=O)N(C)C.Cl.Cl
InChI
InChI=1S/C27H34ClN5O3.2ClH/c1-17-13-19(5-6-22(17)28)16-32-11-9-21(10-12-32)33-23(7-8-25(33)34)26(35)30-24-15-20(14-18(2)29-24)27(36)31(3)4;;/h5-6,13-15,21,23H,7-12,16H2,1-4H3,(H,29,30,35);2*1H/t23-;;/m1../s1
InChIKey
IUDHVSKPEAGQGJ-MQWQBNKOSA-N
Chemical Structure
2D Structure
2D structure of Lazucirnon hydrochloride
CAS: 1372127-19-9
CID: 71767528
Formula: C27H36Cl3N5O3
MW: 585.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight585.0
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass583.188373
Monoisotopic Mass583.188373
Topological Polar Surface Area85.9 Ų
Heavy Atom Count38
Formal Charge0
Complexity802
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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