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ARN22089

CAT: 0013-GTR19235595-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19235595-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN22089 is an orally bioavailable small molecule inhibitor targeting the CDC42 GTPase interaction. It demonstrates in vivo efficacy by suppressing tumor growth in BRAF-mutant melanoma, as validated in mouse models and patient-derived xenografts (PDXs) . This inhibitor is a valuable research tool for studying oncogenic signaling pathways in both cellular and animal studies.
CAS Number
2248691-29-2
Product Name Alternative
ARN 22089
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.37% (May vary between batches)
Smiles
N=1C (=CC (=NC1C2CCNCC2) C=3C=CC=CC3) NC4=CC=CC (=C4) N (C) C
Molecular Formula
C23H27N5
Molecular Weight
373.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Arn22089
CAS Number2248691-29-2
PubChem CID142466546
IUPAC Name3-N,3-N-dimethyl-1-N-(6-phenyl-2-piperidin-4-ylpyrimidin-4-yl)benzene-1,3-diamine
Molecular FormulaC23H27N5
Molecular Weight373.5
XLogP4
Topological Polar Surface Area53.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity458
SMILES
CN(C)C1=CC=CC(=C1)NC2=NC(=NC(=C2)C3=CC=CC=C3)C4CCNCC4
InChI
InChI=1S/C23H27N5/c1-28(2)20-10-6-9-19(15-20)25-22-16-21(17-7-4-3-5-8-17)26-23(27-22)18-11-13-24-14-12-18/h3-10,15-16,18,24H,11-14H2,1-2H3,(H,25,26,27)
InChIKey
BWJICNGLWINASO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Arn22089
CAS: 2248691-29-2
CID: 142466546
Formula: C23H27N5
MW: 373.5
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight373.5
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass373.22664588
Monoisotopic Mass373.22664588
Topological Polar Surface Area53.1 Ų
Heavy Atom Count28
Formal Charge0
Complexity458
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T85727-01ARN22089

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