Hypocrellin B

• Description :

  Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Apoptosis; Fungal; Parasite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/hypocrellin-b.html

• Purity :

  99.61

• Solubility :

  DMSO : < 1 mg/mL (ultrasonic)

• Smiles :

  CC(C1)=C(C(C)=O)C(C2=C(C3=C(O)C=C4OC)C4=C5C(OC)=CC(O)=C6C5=C2C1=C(OC)C6=O)=C(OC)C3=O

• Molecular Formula :

  C30H24O9

• Molecular Weight :

  528.51

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Miller GG, et al. Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update. Photochem Photobiol. 1997 Apr;65 (4) :714-22.|[2]Wang X, et al. Hypocrellin B-mediated sonodynamic action induces apoptosis of hepatocellular carcinoma cells. Ultrasonics. 2012 Apr;52 (4) :543-6.|[3]Ma G, et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother. 2004 Nov;48 (11) :4450-2.|[4]Chang JE, et al. Hypocrellin B and paclitaxel-encapsulated hyaluronic acid-ceramide nanoparticles for targeted photodynamic therapy in lung cancer. J Photochem Photobiol B. 2016 May;158:113-21.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Leishmania

• CAS Number :

  [123940-54-5]