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Terutroban

CAT: 0804-HY-16991-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16991-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Terutroban (S-18886) is a selective and orally active thromboxane-prostaglandin (TP) receptor antagonist with an IC50 of 16.4 nM. Terutroban inhibits TXA2 and prostaglandin endoperoxide receptors. Terutroban is a potent antithrombotic agent and possesses anti-atherosclerotic and anti-vasoconstrictor properties[1][2][3].
CAS Number
165538-40-9
Product Name Alternative
S-18886
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Terutroban.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCC1=C2CC[C@@H](NS(=O)(C3=CC=C(Cl)C=C3)=O)CC2=CC=C1C
Molecular Formula
C20H22ClNO4S
Molecular Weight
407.91
Precautions
H315, H319, H335
References & Citations
[1]Gelosa P, et al. Terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, prevents hypertensive vascular hypertrophy and fibrosis. Am J Physiol Heart Circ Physiol. 2011 Mar;300 (3) :H762-8.|[2]Lesault PF, et al. Daily administration of the TP receptor antagonist terutroban improved endothelial function in high-cardiovascular-risk patients with atherosclerosis. Br J Clin Pharmacol.2011 Jun;71 (6) :844-851.|[3]Wang X, et al. Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2) -receptor antagonists. ACS Med Chem Lett. 2014 Jul 24;5 (9) :1015-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4

Alternative Products

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T5505-01Terutroban
A20884-100Terutroban 100mg
A20884-25Terutroban 25mg
A20884-50Terutroban 50mg
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GTR19274122-01Terutroban sodium
A20884-5Terutroban 5mg
A20884-10mM-DTerutroban 10mM * 1mL in DMSO

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