XL413

• Description:

  XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.

• Product Name Alternative:

  BMS-863233

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/xl413.html

• Purity:

  99.76

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC=C2C(C(N=C([C@@H]3CCCN3)NC4=O)=C4O2)=C1

• Molecular Formula:

  C14H12ClN3O2

• Molecular Weight:

  289.72

• Precautions:

  H302

• References & Citations:

  [1]Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22 (11) :3727-31.|[2]Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9 (11) :e113300.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDC

• Citation 01:

  MedComm (2020) . 2025 May 15;6 (6) :e70150.|Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315 (3) :L360-L370.|Harvard Medical School LINCS LIBRARY|Science. 2017 Dec 1;358 (6367) :eaan4368.|Sens Actuators B Chem. 15 May 2022, 131618.|University of Washington. 2025.

• CAS Number:

  [1169558-38-6]