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Human FasL Protein, His-SUMO tag (Animal-Free)

CAT: 0749-PRP1212-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0749-PRP1212-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FasLis expressed from lymphoid tissue and secreted to blood. Binding to its receptor, TNFRSF6/FAS, leads to induce apoptotic signal into cells. FasL involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development
Description
Fas Ligand (FasL) is a 17.34 kDa tumor necrosis factor with 152 amino acid residues. FasL is expressed from lymphoid tissue and secreted to blood. Binding to its receptor, TNFRSF6/FAS, leads to induce apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development.
Product Name Alternative
Fas ligand, soluble Fas Ligand (sFasL), TNFSF6, CD95L, Apo I Ligand, APTL, APT1LG1, CD178
Gene ID
356
Accession Number
P48023
Tag
FasL
Type
Cytokines and proteins
Applications
His-SUMO tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Measure by its ability to induce apoptosis in Jurkat cells. The ED₅₀ for this effect is <1 ng/mL. The specific activity of recombinant human FasL is > 1 x 10⁶ IU/mg.
Molecular Formula
29.51 kDa
Molecular Weight
29.51 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin : < 0.1 EU per 1 μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized protein product should be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (5% HSA,10% FBS or 0.1%BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant Human FasL Protein consists of 152 amino acids and predicts a molecular mass of 29.51 kDa.
Formulation
Lyophilized from sterile PBS, pH 8.0.
Applications Notes
Human
Other Product Names
FASL, FasL, fas ligand, soluble Fas Ligand (sFasL), TNFSF6, CD95L, Apo I Ligand, APTL, APT1LG1, CD178
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously.
Preparation
E.coli
Accession Number URL
https://www.uniprot.org/uniprotkb/P48023/entry
AA Sequence
Amino acid sequence derived from Human FasL Protein (Gln130-Leu281) (P48023-1) was expressed with 6xHis and SUMO tag at the N-terminus.

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