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ARD-1676

CAT: 0013-GTR19230318-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19230318-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARD-1676 is an orally bioavailable PROTAC degrader targeting the androgen receptor (AR) for research use. It effectively degrades AR in cellular assays and suppresses tumor growth in VCaP xenograft models, supporting its investigation in prostate cancer research.
CAS Number
2632305-36-1
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
C[C@H]1CC2 (CN1C3=CC (Cl) =C (C#N) C=C3) CCN (CC2) C4=CC=C (C (=O) N5CCC (CN6CC=7C (C6) =CC8=C (C7) C (=O) N (C8=O) C9C (=O) NC (=O) CC9) CC5) C=C4
Molecular Formula
C44H46ClN7O5
Molecular Weight
788.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pak8EC5gpr
CAS Number2632305-36-1
PubChem CID156180706
IUPAC Name2-chloro-4-[(3S)-8-[4-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-5,7-dihydropyrrolo[3,4-f]isoindol-6-yl]methyl]piperidine-1-carbonyl]phenyl]-3-methyl-2,8-diazaspiro[4.5]decan-2-yl]benzonitrile
Molecular FormulaC44H46ClN7O5
Molecular Weight788.3
XLogP4.9
Topological Polar Surface Area137
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count57
Formal Charge0
Complexity1610
SMILES
C[C@H]1CC2(CCN(CC2)C3=CC=C(C=C3)C(=O)N4CCC(CC4)CN5CC6=CC7=C(C=C6C5)C(=O)N(C7=O)C8CCC(=O)NC8=O)CN1C9=CC(=C(C=C9)C#N)Cl
InChI
InChI=1S/C44H46ClN7O5/c1-27-21-44(26-51(27)34-7-4-30(22-46)37(45)20-34)12-16-49(17-13-44)33-5-2-29(3-6-33)41(55)50-14-10-28(11-15-50)23-48-24-31-18-35-36(19-32(31)25-48)43(57)52(42(35)56)38-8-9-39(53)47-40(38)54/h2-7,18-20,27-28,38H,8-17,21,23-26H2,1H3,(H,47,53,54)/t27-,38?/m0/s1
InChIKey
GAXWAKXJBZHVQF-ZVENJKCTSA-N
Chemical Structure
2D Structure
2D structure of Pak8EC5gpr
CAS: 2632305-36-1
CID: 156180706
Formula: C44H46ClN7O5
MW: 788.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight788.3
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass787.3248953
Monoisotopic Mass787.3248953
Topological Polar Surface Area137 Ų
Heavy Atom Count57
Formal Charge0
Complexity1610
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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