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TNG-462

CAT: 0013-GTR19230185-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19230185-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNG-462 is an orally active, potent, and selective PRMT5 inhibitor. It demonstrates antitumor efficacy in preclinical models, particularly for cancers with MTAP-deficiency or MTA accumulation, such as certain solid tumors and hematologic malignancies. Its activity has been validated in both in vitro cellular assays and in vivo xenograft studies.
CAS Number
2760483-96-1
Product Name Alternative
HistoneMethyltransferase, Histone Methyltransferase, TNG462
Field of Research
Epigenetics & Chromatin
Purity
98.70% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.34 mM) ; DMSO:80 mg/mL (153.64 mM)
Smiles
C (C (NC=1C=C (CC) C (N) =NC1) =O) (=O) N2[C@H] (CC[C@H] (C) C2) C=3C=C4C (=CC3) SC (=N4) C5CCN (C) CC5
Molecular Formula
C28H36N6O2S
Molecular Weight
520.69
Storage Conditions
-20°C
Notes
For research use only.

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