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YW1128

CAT: 0804-HY-133180-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133180-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YW1128 (compound 3a) is a potent Wnt/β-Catenin inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism[1].
CAS Number
2131223-64-6
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/yw1128.html
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
O=C(C1=C(C)N(C2=CC=CC=C2C)N=N1)NC3=NC4=CC=CC=C4C=C3
Molecular Formula
C20H17N5O
Molecular Weight
343.38
References & Citations
[1]Obianom ON, et al. Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice. J Med Chem. 2019 Jan 24;62 (2) :727-741.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA9102-10YW1128

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