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SCH79797

CAT: 0804-HY-14993-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14993-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes[1][2][3][4].
CAS Number
245520-69-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sch79797.html
Purity
99.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=NC(NC2CC2)=NC3=CC=C(N(CC4=CC=C(C(C)C)C=C4)C=C5)C5=C31
Molecular Formula
C23H25N5
Molecular Weight
371.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Ahn HS, et al. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4- (1-methylethyl) phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem Pharmacol. 2000 Nov 15;60 (10) :1425-34.|[2]Di Serio C, et al. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Basic Clin Pharmacol Toxicol. 2007 Jul;101 (1) :63-9.|[3]Sokolova E, et al. A novel therapeutic target in various lung diseases: airway proteases and protease-activated receptors. Pharmacol Ther. 2007 Jul;115 (1) :70-83.|[4]Strande JL, et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Basic Res Cardiol. 2007 Jul;102 (4) :350-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR1
Citation 01
Exp Mol Med. 2024 Dec;56 (12) :2631-2641.|J Appl Toxicol. 2025 Sep 1.|J Immunother Cancer. 2025 Jul 13;13 (7) :e010898.|Res Sq. 2024 Sep 04.|iScience. 2021 Oct 30;24 (11) :103386.

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