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Ossirene

CAT: 0804-HY-101019-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101019-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor[1]. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies[2][3][4].
CAS Number
106566-58-9
Product Name Alternative
AS101
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Caspase; Interleukin Related
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ossirene.html
Purity
98.0
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[Cl-][Te+4]1([Cl-])([Cl-])[O-]CC[O-]1.[NH4+]
Molecular Formula
C2H8Cl3NO2Te
Molecular Weight
312.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Sredni B, et al. Ammonium trichloro (dioxoethylene-o, o') tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res. 2004 Mar 1;64 (5) :1843-52.|[2]Yona Kalechman, et al. Inhibition of interleukin-10 by the Immunomodulator AS101 Reduces Mesangial Cell Proliferation in Experimental Mesangioproliferative Glomerulonephritis: Association With Dephosphorylation of STAT3. J Biol Chem. 2004 Jun 4;279 (23) :24724-32.|[3]Diamond Ling, et al. The Tellurium Redox Immunomodulating Compound AS101 Inhibits IL-1β-activated Inflammation in the Human Retinal Pigment Epithelium. Br J Ophthalmol. 2013 Jul;97 (7) :934-8.|[4]Yafit Hachmo, et al. The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association With Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation. Front Immunol. 2017 Mar 7;8:240.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Caspase 1; IL-1; IL-10; IL-6; IL-8

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A16414-5Ossirene (AS101) 5mg
A16414-200Ossirene (AS101) 200mg
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