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PERK/eIF2α activator 1

CAT: 0013-GTR19234800-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19234800-02Size:50 mg
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Description
Compound V8 (PERK/eIF2α activator 1) is a flavonoid that triggers apoptosis and activates the PERK-eIF2α-ATF4 signaling pathway, demonstrating anti-proliferative effects in HepG2 cells with an IC50 of 23 μM. It serves as a research tool for investigating ER stress, cancer biology, and cell death mechanisms in vitro.
CAS Number
1178583-17-9
Field of Research
Cell Biology
Smiles
O (C) C1=C2C (C (=O) C=C (O2) C3=CC=CC=C3) =C (O) C=C1OCCCCN (CCO) CCO
Molecular Formula
C24H29NO7
Molecular Weight
443.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PERK/eIF2|A activator 1
CAS Number1178583-17-9
PubChem CID72203535
IUPAC Name7-[4-[bis(2-hydroxyethyl)amino]butoxy]-5-hydroxy-8-methoxy-2-phenylchromen-4-one
Molecular FormulaC24H29NO7
Molecular Weight443.5
XLogP2.7
Topological Polar Surface Area109
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count12
Heavy Atom Count32
Formal Charge0
Complexity601
SMILES
COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)OCCCCN(CCO)CCO
InChI
InChI=1S/C24H29NO7/c1-30-23-21(31-14-6-5-9-25(10-12-26)11-13-27)16-19(29)22-18(28)15-20(32-24(22)23)17-7-3-2-4-8-17/h2-4,7-8,15-16,26-27,29H,5-6,9-14H2,1H3
InChIKey
QWQDULIQJQIEKB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PERK/eIF2|A activator 1
CAS: 1178583-17-9
CID: 72203535
Formula: C24H29NO7
MW: 443.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.5
XLogP32.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count12
Exact Mass443.19440226
Monoisotopic Mass443.19440226
Topological Polar Surface Area109 Ų
Heavy Atom Count32
Formal Charge0
Complexity601
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-158196-01PERK/eIF2α activator 1
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