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Hetrombopag olamine

CAT: 0013-GTR19224369-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19224369-02Size:50 mg
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Description
Hetrombopag olamine is an orally bioavailable, small molecule agonist of the thrombopoietin receptor. It is used in research to study megakaryopoiesis and platelet production, with applications in both in vitro cellular assays and in vivo models of thrombocytopenia.
CAS Number
1257792-42-9
Field of Research
Immunology & Inflammation
Smiles
NCCO.NCCO.CC1=NN (C (=O) \C1=N/Nc1cccc (-c2ccc (o2) C (O) =O) c1O) c1ccc2CCCCc2c1
Molecular Formula
C29H36N6O7
Molecular Weight
580.63
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Hetrombopag olamine

Hetrombopag Olamine is the orally active ethanolamine salt of hetrombopag, a small-molecule, nonpeptide thrombopoietin receptor (TPO-R or CD110) agonist, with megakaryopoiesis-stimulating activity. Upon oral administration, hetrombopag targets, binds to and stimulates the transmembrane domain of the platelet TPO-R, a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. This may prevent or treat chemotherapy-induced thrombocytopenia.

CAS Number1257792-42-9
PubChem CID135565609
IUPAC Namebis(2-aminoethanol);5-[2-hydroxy-3-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-4-yl]diazenyl]phenyl]furan-2-carboxylic acid
Molecular FormulaC29H36N6O7
Molecular Weight580.6
Topological Polar Surface Area220
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count12
Rotatable Bond Count7
Heavy Atom Count42
Formal Charge0
Complexity870
SMILES
CC1=C(C(=O)N(N1)C2=CC3=C(CCCC3)C=C2)N=NC4=CC=CC(=C4O)C5=CC=C(O5)C(=O)O.C(CO)N.C(CO)N
InChI
InChI=1S/C25H22N4O5.2C2H7NO/c1-14-22(24(31)29(28-14)17-10-9-15-5-2-3-6-16(15)13-17)27-26-19-8-4-7-18(23(19)30)20-11-12-21(34-20)25(32)33;2*3-1-2-4/h4,7-13,28,30H,2-3,5-6H2,1H3,(H,32,33);2*4H,1-3H2
InChIKey
RKEJRDZRWWDSRX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hetrombopag olamine
CAS: 1257792-42-9
CID: 135565609
Formula: C29H36N6O7
MW: 580.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight580.6
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count12
Rotatable Bond Count7
Exact Mass580.26454751
Monoisotopic Mass580.26454751
Topological Polar Surface Area220 Ų
Heavy Atom Count42
Formal Charge0
Complexity870
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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