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VU0477886

CAT: 0013-GTR19224267-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19224267-02Size:50 mg
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Description
VU0477886 is a potent and selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4) . It demonstrates robust efficacy in preclinical models such as haloperidol-induced catalepsy, supporting its research application in Parkinson's disease and related neurological disorders.
CAS Number
1926222-30-1
Field of Research
Neuroscience
Smiles
O=C (C1=NC=CC=C1N) NC2=CC=C (N (C (C3=C4C=CC=C3) =O) C4=O) C (Cl) =C2
Molecular Formula
C20H13ClN4O3
Molecular Weight
392.80
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-amino-N-[3-chloro-4-(1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide
CAS Number1926222-30-1
PubChem CID127046557
IUPAC Name3-amino-N-[3-chloro-4-(1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide
Molecular FormulaC20H13ClN4O3
Molecular Weight392.8
XLogP3.1
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity621
SMILES
C1=CC=C2C(=C1)C(=O)N(C2=O)C3=C(C=C(C=C3)NC(=O)C4=C(C=CC=N4)N)Cl
InChI
InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)
InChIKey
XBKGMJNNALFSAJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-amino-N-[3-chloro-4-(1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide
CAS: 1926222-30-1
CID: 127046557
Formula: C20H13ClN4O3
MW: 392.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight392.8
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass392.0676180
Monoisotopic Mass392.0676180
Topological Polar Surface Area105 Ų
Heavy Atom Count28
Formal Charge0
Complexity621
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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