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Lotilaner

CAT: 0804-HY-116564-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116564-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1].
CAS Number
1369852-71-0
UNSPSC
12352005
Target
GABA Receptor; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lotilaner.html
Purity
99.84
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCC(NCC(F)(F)F)=O)C1=C(C=C(S1)C2=NO[C@](C3=CC(Cl)=C(C(Cl)=C3)Cl)(C2)C(F)(F)F)C
Molecular Formula
C20H14Cl3F6N3O3S
Molecular Weight
596.76
References & Citations
[1]Lotilaner, et al. The novel isoxazoline ectoparasiticide lotilaner (Credelio™) : a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls) . Parasit Vectors. 2017 Nov 1;10 (1) :530.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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