MPP (hydrochloride)

CAT:

804-HY-103454B-04

Size:

25 mg

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Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

MPP (hydrochloride)

CAS Number: 2863676-89-3
UNSPSC Description: MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1].
Target Antigen: Apoptosis; Estrogen Receptor/ERR
Type: Reference compound
Related Pathways: Apoptosis;Vitamin D Related/Nuclear Receptor
Applications: Cancer-programmed cell death
Field of Research: Cancer; Endocrinology
Assay Protocol: https://www.medchemexpress.com/mpp-hydrochloride.html
Purity: 99.28
Solubility: DMSO : 250 mg/mL (ultrasonic)
Smiles: OC1=CC=C(C2=NN(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)=C2C)C=C1.[H]Cl
Molecular Weight: 506.04
References & Citations: [1]Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73(8):1034-44.|[2]Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672.|[3]Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94.Metab Brain Dis. 2022 Jul 2.|Biochem Pharmacol. 2024 May 9:225:116256.|Food Chem Toxicol. 2023 Apr 18;113792.|Biomolecules. 2023 Jul 10, 13(7), 1097.|Drug Resist Updat. 2023 Oct 26:71:101014.|Ecotoxicol Environ Saf. 2023 May 23;259:115060.|Eur J Inflamm. October 11, 2021.|Mol Nutr Food Res. 2021 Jul 5;e2100070.|Phytomedicine. 2023 Nov 14:123:155218.|Phytomedicine. 27 February 2022, 154022.
Shipping Conditions: Room Temperature
Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
Clinical Information: No Development Reported

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