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Graveoline

CAT: 0804-HY-12538-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12538-01Size:100 mg
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Description
Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candida albicans. Graveoline can be used in the research of various diseases such as tumors and liver injury[1][2][3][4].
CAS Number
485-61-0
Product Name Alternative
Rutamine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Fungal; Interleukin Related; JAK; Parasite; Reactive Oxygen Species (ROS) ; STAT
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/graveoline.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C(C2=CC=C(OCO3)C3=C2)N(C)C4=C1C=CC=C4
Molecular Formula
C17H13NO3
Molecular Weight
279.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Ghosh S, et, al. Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. Phytother Res. 2014 Aug;28 (8) :1153-62.|[2]Kamal LZM, et, al. Identification of Alkaloid Compounds Arborinine and Graveoline from Ruta angustifolia (L.) Pers for their Antifungal Potential against Isocitrate lyase (ICL1) gene of Candida albicans. Mycopathologia. 2021 May;186 (2) :221-236.|[3]Rodríguez-Garza NE, et al. Antiparasitic Activity of Chalepensin and Graveoline Isolated from Ruta chalepensis L.: In Vitro Evaluation Against Strongyloides venezuelensis. Pathogens. 2025 Apr 25;14 (5) :419.|[4]He J, et al. Graveoline attenuates D-GalN/LPS-induced acute liver injury via inhibition of JAK1/STAT3 signaling pathway. Biomed Pharmacother. 2024 Aug;177:117163.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-10; IL-4; JAK1; STAT3

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CatalogName
MBS5765305Graveoline
A13917-10Graveoline 10mg
A13917-5Graveoline 5mg
A13917-2Graveoline 2mg
A13917-50Graveoline 50mg
A13917-25Graveoline 25mg
A13917-10mM-DGraveoline 10mM * 1mL in DMSO

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