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JB170

CAT: 0013-GTR19221447-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19221447-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JB170 is a potent and selective PROTAC degrader of Aurora A kinase, demonstrating a DC50 of 28 nM and a ten-fold selectivity over Aurora B. It induces S-phase cell cycle arrest and disrupts the non-catalytic functions of Aurora A, making it a valuable chemical probe for studying oncogenic kinase signaling in cancer research models.
CAS Number
2705844-82-0
Product Name Alternative
JB 170
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
99.82% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (3.43 mM) ; DMSO:80 mg/mL (83.04 mM)
Smiles
O=C (NCCOCCOCCNC (=O) COC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3) C4=CC=C (C=C4OC) NC=5N=CC6=C (N5) C=7C=CC (Cl) =CC7C (=NC6) C=8C (F) =CC=CC8OC
Molecular Formula
C48H44ClFN8O11
Molecular Weight
963.36
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
MBS5816172JB170

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