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MS9427 TFA

CAT: 0013-GTR19221075-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19221075-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS9427 TFA is a potent and selective PROTAC degrader of mutant EGFR (L858R), with high affinity for both wild-type (Kd=7.1 nM) and mutant (Kd=4.3 nM) forms. It induces degradation via UPS and autophagy pathways, demonstrating efficacy in inhibiting NSCLC cell proliferation in vitro, supporting its use in targeted cancer therapy research.
Field of Research
Cardiovascular Research, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C50H59ClF4N8O14
Molecular Weight
1107.5
Storage Conditions
-20°C
Notes
For research use only.

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