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Indacrinone

CAT: 0804-HY-U00242-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00242-04Size:50 mg
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Description
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
CAS Number
56049-88-8
Product Name Alternative
MK-196; Indacrynic acid
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/MK196.html
Purity
99.89
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)COC1=CC2=C(C(C(C3=CC=CC=C3)(C)C2)=O)C(Cl)=C1Cl
Molecular Formula
C18H14Cl2O4
Molecular Weight
365.21
References & Citations
[1]A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Indacrinone

Indacrinone is an orally active, indanone-based loop diuretic that consists of a racemic mixture. The (-) enantiomer is natriuretic, and the (+) enantiomer is uricosuric.

CAS Number56049-88-8
PubChem CID42266
IUPAC Name2-[(6,7-dichloro-2-methyl-1-oxo-2-phenyl-3H-inden-5-yl)oxy]acetic acid
Molecular FormulaC18H14Cl2O4
Molecular Weight365.2
XLogP4.5
Topological Polar Surface Area63.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity505
SMILES
CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3=CC=CC=C3
InChI
InChI=1S/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22)
InChIKey
PRKWVSHZYDOZLP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Indacrinone
CAS: 56049-88-8
CID: 42266
Formula: C18H14Cl2O4
MW: 365.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.2
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass364.0269143
Monoisotopic Mass364.0269143
Topological Polar Surface Area63.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity505
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5771971Indacrinone

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