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UBX1325

CAT: 0013-GTR19220845-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220845-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UBX1325 is a senolytic small molecule that inhibits Bcl-xL to selectively induce apoptosis in senescent cells. Its potential in treating age-related pathologies is being explored in preclinical research for ocular diseases such as diabetic macular edema (DME), age-related macular degeneration (AMD), and diabetic retinopathy.
CAS Number
2271269-01-1
Field of Research
Cell Biology
Smiles
C (O) (=O) C=1C (=C (N (C (C) C) C1C) C2=CC=C (Cl) C=C2) C3=CC (=CC=C3) N4CCN (CC4) C5=CC=C (NS (=O) (=O) C6=CC (S (C (F) (F) F) (=O) =O) =C (N[C@H] (CCN7CCC (OP (=O) (O) O) CC7) CSC8=CC=CC=C8) C=C6) C=C5
Molecular Formula
C53H59ClF3N6O10PS3
Molecular Weight
1159.69
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Foselutoclax

Foselutoclax is a small molecule drug. The usage of the INN stem '-toclax' in the name indicates that Foselutoclax is a B-cell lymphoma 2 (Bcl-2) inhibitor. Foselutoclax is under investigation in clinical trial NCT06011798 (Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE)). Foselutoclax has a monoisotopic molecular weight of 1158.28 Da.

CAS Number2271269-01-1
PubChem CID147562879
IUPAC Name5-(4-chlorophenyl)-2-methyl-4-[3-[4-[4-[[4-[[(2R)-1-phenylsulfanyl-4-(4-phosphonooxypiperidin-1-yl)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylamino]phenyl]piperazin-1-yl]phenyl]-1-propan-2-ylpyrrole-3-carboxylic acid
Molecular FormulaC53H59ClF3N6O10PS3
Molecular Weight1159.7
XLogP7.6
Topological Polar Surface Area253
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count19
Rotatable Bond Count20
Heavy Atom Count77
Formal Charge0
Complexity2160
SMILES
CC1=C(C(=C(N1C(C)C)C2=CC=C(C=C2)Cl)C3=CC(=CC=C3)N4CCN(CC4)C5=CC=C(C=C5)NS(=O)(=O)C6=CC(=C(C=C6)N[C@H](CCN7CCC(CC7)OP(=O)(O)O)CSC8=CC=CC=C8)S(=O)(=O)C(F)(F)F)C(=O)O
InChI
InChI=1S/C53H59ClF3N6O10PS3/c1-35(2)63-36(3)49(52(64)65)50(51(63)37-12-14-39(54)15-13-37)38-8-7-9-43(32-38)62-30-28-61(29-31-62)42-18-16-40(17-19-42)59-77(71,72)46-20-21-47(48(33-46)76(69,70)53(55,56)57)58-41(34-75-45-10-5-4-6-11-45)22-25-60-26-23-44(24-27-60)73-74(66,67)68/h4-21,32-33,35,41,44,58-59H,22-31,34H2,1-3H3,(H,64,65)(H2,66,67,68)/t41-/m1/s1
InChIKey
FSZILRQCEAUYPL-VQJSHJPSSA-N
Chemical Structure
2D Structure
2D structure of Foselutoclax
CAS: 2271269-01-1
CID: 147562879
Formula: C53H59ClF3N6O10PS3
MW: 1159.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1159.7
XLogP37.6
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count19
Rotatable Bond Count20
Exact Mass1158.2833048
Monoisotopic Mass1158.2833048
Topological Polar Surface Area253 Ų
Heavy Atom Count77
Formal Charge0
Complexity2160
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS5816802UBX1325

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