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UP163

CAT: 0804-HY-168323-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168323-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132 -induced TDP-43 aggregates[1].
CAS Number
591242-60-3
UNSPSC
12352005
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/up163.html
Purity
98.08
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CO1)OCCN(C2=NS(=O)(C3=C2C=CC=C3)=O)C4=CC=C(C=C4)Cl
Molecular Formula
C20H15ClN2O5S
Molecular Weight
430.86
References & Citations
[1]Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134 (14) :e169039.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19241215-01UP163

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