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GLPG2534

CAT: 0013-GTR19220609-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220609-02Size:5 mg
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Description
GLPG2534 is a potent and selective orally active IRAK4 inhibitor with demonstrated anti-inflammatory activity in both human and mouse systems. It serves as a key research tool for investigating inflammatory skin diseases such as psoriasis and atopic dermatitis in both in vitro and in vivo experimental models.
CAS Number
2095615-97-5
Product Name Alternative
IRAK-4, GLPG-2534
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
99.21% (May vary between batches)
Solubility
DMSO:80 mg/mL (188.48 mM)
Smiles
N#CC1=CN=C (C=C1) N2C=NC=3C=C (OCCOCCO) C (=NC32) NC4CCOCC4
Molecular Formula
C21H24N6O4
Molecular Weight
424.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 129053583
CAS Number2095615-97-5
PubChem CID129053583
IUPAC Name6-[6-[2-(2-hydroxyethoxy)ethoxy]-5-(oxan-4-ylamino)imidazo[4,5-b]pyridin-3-yl]pyridine-3-carbonitrile
Molecular FormulaC21H24N6O4
Molecular Weight424.5
XLogP1.2
Topological Polar Surface Area127
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count31
Formal Charge0
Complexity598
SMILES
C1COCCC1NC2=C(C=C3C(=N2)N(C=N3)C4=NC=C(C=C4)C#N)OCCOCCO
InChI
InChI=1S/C21H24N6O4/c22-12-15-1-2-19(23-13-15)27-14-24-17-11-18(31-10-9-30-8-5-28)20(26-21(17)27)25-16-3-6-29-7-4-16/h1-2,11,13-14,16,28H,3-10H2,(H,25,26)
InChIKey
VNAPWQDUDZCVCA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 129053583
CAS: 2095615-97-5
CID: 129053583
Formula: C21H24N6O4
MW: 424.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight424.5
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass424.18590327
Monoisotopic Mass424.18590327
Topological Polar Surface Area127 Ų
Heavy Atom Count31
Formal Charge0
Complexity598
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA6060-1GLPG2534

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