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CST 905

CAT: 0013-GTR19219804Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19219804Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CST 905 is a potent and selective PROTAC degrader of BRAF V600E (DC50 = 18 nM), utilizing a VHL ligand and a PLX-derived warhead connected by a linker. Unlike some degraders, it avoids ERK activation, making it a valuable tool for studying oncogenic BRAF signaling and resistance mechanisms in both cellular and in vivo cancer models.
Smiles
FC1=C (C (F) =CC=C1NS (N (C) CC) (=O) =O) C (C2=CNC3=C2C=C (C=N3) C4=CC=C (C=C4) N5CCN (CC5) CC (N[C@H] (C (N6[C@@H] (C[C@H] (C6) O) C (NCC7=CC=C (C=C7) C8=C (N=CS8) C) =O) =O) C (C) (C) C) =O) =O
Molecular Formula
C51H58F2N10O7S2
Molecular Weight
1025.20
Storage Conditions
-20°C
Notes
For research use only.

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