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Vapitadine

CAT: 0013-GTR19219690-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19219690-02Size:5 mg
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Description
Vapitadine is a non-sedating antihistamine compound used in research to alleviate pruritus associated with atopic dermatitis. It is applied in pharmacological studies to investigate histamine-mediated pathways in both in vitro cellular assays and in vivo models of allergic skin inflammation.
CAS Number
793655-64-8
Product Name Alternative
R129160, R-129160, R 129160, Vapitadine, Histamine Receptor, HistamineReceptor
Field of Research
Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery
Purity
99.77% (May vary between batches)
Smiles
O=C (N) C1=CN=C2N1CCC=3C=CC=CC3C24CCNCC4
Molecular Formula
C17H20N4O
Molecular Weight
296.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Vapitadine

Vapitadine is an antihistamine that Barrier Therapeutics is developing as a treatment for allergic reactions of the skin, such as those associated with hives and for the itch associated with atopic dermatitis. An advantage of vapitadine over other antihistamines may be the absence of the sedation, even at high doses.

CAS Number793655-64-8
PubChem CID9842252
IUPAC Namespiro[5,6-dihydroimidazo[2,1-b][3]benzazepine-11,4'-piperidine]-3-carboxamide
Molecular FormulaC17H20N4O
Molecular Weight296.37
XLogP1
Topological Polar Surface Area72.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count22
Formal Charge0
Complexity434
SMILES
C1CN2C(=CN=C2C3(CCNCC3)C4=CC=CC=C41)C(=O)N
InChI
InChI=1S/C17H20N4O/c18-15(22)14-11-20-16-17(6-8-19-9-7-17)13-4-2-1-3-12(13)5-10-21(14)16/h1-4,11,19H,5-10H2,(H2,18,22)
InChIKey
VQWGYPVNVICKFC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Vapitadine
CAS: 793655-64-8
CID: 9842252
Formula: C17H20N4O
MW: 296.37
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.37
XLogP31
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass296.16371127
Monoisotopic Mass296.16371127
Topological Polar Surface Area72.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity434
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T29096L-01Vapitadine
T29096-01Vapitadine dihydrochloride
HY-14939A-01Vapitadine (hydrochloride)

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