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Zoldonrasib

CAT: 0013-GTR19219813-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19219813-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RMC-9805 is a covalent, oral, and mutant-selective inhibitor targeting the active state of KRASG12D. It functions by forming a stable, high-affinity complex with KRASG12D and cyclophilin A, blocking downstream signaling. This mechanism has demonstrated induction of apoptosis and tumor regression in preclinical in vivo and in vitro models of KRASG12D-driven cancers.
CAS Number
2922732-54-3
Product Name Alternative
KRAS G12D, KRAS G12D IN 18, KRAS G12D inhibitor 18, Zoldonrasib
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.10% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.28 mM) ; DMSO:252.5 mg/mL (216.1 mM)
Smiles
O=C1OCC (C) (C) CC=2C3=CC (=CC=C3N (C2C4=CC (=CN=C4C (OC) C) N5CCN (CC5) C6CC6) CC (F) (F) F) N7CCOC (C7) CC (NC (=O) C (N8CCC9 (CN (C (=O) C%10N (C) C%10C%11CC%11) CC9) C8) C%12CCCC%12) C (=O) N%13NC1CCC%13
Molecular Formula
C63H88F3N11O7
Molecular Weight
1168.44
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

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HY-156819-01Zoldonrasib
C01981-25mgZoldonrasib (RMC-9805)
A24224-10Zoldonrasib (RMC-9805) 10mg
A24224-5Zoldonrasib (RMC-9805) 5mg
A24224-50Zoldonrasib (RMC-9805) 50mg
A24224-1Zoldonrasib (RMC-9805) 1mg

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