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DNL343

CAT: 0013-GTR19218851-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19218851-05Size:25 mg
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Description
DNL343 is a brain-penetrant, selective eIF2B activator that suppresses stress granule formation driven by C9ORF72 dipeptide repeats. This molecule is a valuable research tool for investigating pathogenic mechanisms and potential therapeutic strategies in ALS and related neurodegenerative diseases, with utility in both cellular and animal models.
CAS Number
2278265-85-1
Product Name Alternative
EIF2B, DNL 343, DNL-343
Field of Research
Cell Biology
Purity
99.96% (May vary between batches)
Solubility
DMSO:80 mg/mL (174.74 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.21 mM)
Smiles
N (C (COC1=CC=C (Cl) C=C1) =O) C23CC (C2) (C3) C=4OC (=NN4) [C@@H]5C[C@H] (OC (F) (F) F) C5
Molecular Formula
C20H19ClF3N3O4
Molecular Weight
457.83
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Evetifator

DNL343 is under investigation in clinical trial NCT05842941 (HEALEY ALS Platform Trial - Regimen G DNL343).

CAS Number2278265-85-1
PubChem CID137491382
IUPAC Name2-(4-chlorophenoxy)-N-[3-[5-[3-(trifluoromethoxy)cyclobutyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]acetamide
Molecular FormulaC20H19ClF3N3O4
Molecular Weight457.8
XLogP3.7
Topological Polar Surface Area86.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count31
Formal Charge0
Complexity678
SMILES
C1C(CC1OC(F)(F)F)C2=NN=C(O2)C34CC(C3)(C4)NC(=O)COC5=CC=C(C=C5)Cl
InChI
InChI=1S/C20H19ClF3N3O4/c21-12-1-3-13(4-2-12)29-7-15(28)25-19-8-18(9-19,10-19)17-27-26-16(30-17)11-5-14(6-11)31-20(22,23)24/h1-4,11,14H,5-10H2,(H,25,28)
InChIKey
IKPNRMYDOSNVAU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Evetifator
CAS: 2278265-85-1
CID: 137491382
Formula: C20H19ClF3N3O4
MW: 457.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight457.8
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass457.1016183
Monoisotopic Mass457.1016183
Topological Polar Surface Area86.5 Ų
Heavy Atom Count31
Formal Charge0
Complexity678
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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