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Semapimod

CAT: 0013-GTR19218711-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19218711-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Semapimod is a small molecule that potently inhibits TLR4 signaling (IC50 ~0.3 μM) and suppresses proinflammatory mediators like TNF-α, IL-1β, IL-6, and nitric oxide. Its mechanism, involving p38 MAPK inhibition, supports its research application in models of sepsis, rheumatoid arthritis, and inflammatory bowel disease both in vitro and in vivo.
CAS Number
352513-83-8
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
C (=NNC (=N) N) (C) C1=CC (C (=NNC (=N) N) C) =CC (NC (CCCCCCCCC (NC2=CC (C (=NNC (=N) N) C) =CC (C (=NNC (=N) N) C) =C2) =O) =O) =C1
Molecular Formula
C34H52N18O2
Molecular Weight
744.9
Storage Conditions
-20°C
Notes
For research use only.

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CatalogName
M14201Semapimod
PGA30151Semapimod tetrahydrochloride
T34610LSemapimod mesylate
M12498-01Semapimod hydrochloride
HY-15509A-01Semapimod (tetrahydrochloride)
T34610Semapimod hydrochloride dihydrate

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