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AS 2444697

CAT: 0013-GTR19217866-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217866-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1; inhibited IL-1β- or TLR ligand lipopolysaccharide (LPS) -induced IL-6 production in human lung alveolar epithelial cells, fibroblast-like synoviocytes, and peripheral blood mononuclear cells; significantly reduces urinary protein excretion and preventd the development of glomerulosclerosis and interstitial fibrosis without affecting the blood pressure in mice model of chronic kidney disease.
CAS Number
1287665-60-4
Product Name Alternative
AS2444697 | AS-2444697
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 12.5 mg/mL (28.88 mM)
Smiles
CC1=NC=CC (=C1) C2=NC (=CO2) C (=O) NC3=CN (N=C3C (=O) N) C4CCOCC4.Cl
Molecular Formula
C19H21ClN6O4
Molecular Weight
432.865
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[3-carbamoyl-1- (tetrahydro-2H-pyran-4-yl) -1H-pyrazol-4-yl]-2- (2-methylpyridin-4-yl) -1,3-oxazole-4-carboxamide hydrochloride

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Alternative Products

CatalogName
441804-01AS 2444697
BUP12874-01AS-2444697
A17186-100AS 2444697 100mg
A17186-25AS 2444697 25mg
A17186-10AS 2444697 10mg
A17186-5AS 2444697 5mg
530638AS-2444697 HCl
B1585-5AS-2444697 Hydrochloride
A17186-200AS 2444697 200mg
A17186-50AS 2444697 50mg

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