Products for Research Use Only
RegisterLogin

ATR-101

CAT: 0013-GTR19217863-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19217863-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.Cushing Disease Phase 2 Clinical (In Vitro) :Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.
CAS Number
133825-81-7
Product Name Alternative
PD-132301 | PD132301-2 | ATR 101 | Nevanimibe
Field of Research
Epigenetics & Chromatin
Purity
>98% (HPLC)
Solubility
DMSO : 41.67 mg/mL. 90.97 mM
Smiles
CC (C) C1=C (C (=CC=C1) C (C) C) NC (=O) NCC2 (CCCC2) C3=CC=C (C=C3) N (C) C.Cl
Molecular Formula
C27H40ClN3O
Molecular Weight
458.09
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (2,6-diisopropylphenyl) -3- ((1- (4- (dimethylamino) phenyl) cyclopentyl) methyl) urea hydrochloride

Related Products

CatalogName
GTR19218828-01ATR-IN-23
GTR17948830ATR Antibody
GTR17930471-01ATR Antibody
GTR18587391-01ATR Antibody
GTR17927223ATR Antibody
GTR19274212-01ATR-IN-32
GTR19263184-01ATR-258
GTR18147042ATR Antibody
GTR18135122ATR Antibody
GTR18077849ATR Antibody

Alternative Products

CatalogName
MBS3840342-01ATR-101
206150ATR-101 HCl
MBS3601356-01ATR-101 free base
A14395-25Nevanimibe (ATR-101) 25mg
A14395-50Nevanimibe (ATR-101) 50mg
A14395-100Nevanimibe (ATR-101) 100mg
A14395-10Nevanimibe (ATR-101) 10mg
A14395-5Nevanimibe (ATR-101) 5mg
552471ATR
70R-34441ATR antibody

Popular Products