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KPT-330

CAT: 0013-GTR19217854-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217854-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KPT-330 inhibited proliferation and induced cell cycle arrest and apoptosis-related proteins in 11 NSCLC cells lines. Moreover, the combination of KPT-330 with cisplatin synergistically enhanced the cell kill of the NSCLC cells in vitro. Human NSCLC tumours growing in immunodeficient mice were markedly inhibited by KPT-330. Also, KPT-330 was effective even against NSCLC cells with a transforming mutation of either exon 20 of EGFR, TP53, phosphatase and tensin homologue, RAS or PIK3CA, suggesting the drug might be effective against a variety of lung Ys irrespective of their driver mutation.
CAS Number
1421923-86-5
Product Name Alternative
(E) -RN
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
C1=CN=C (C=N1) NNC (=O) /C=C/N2C=NC (=N2) C3=CC (=CC (=C3) C (F) (F) F) C (F) (F) F
Molecular Formula
C17H11F6N7O
Molecular Weight
443.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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