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SR8278

CAT: 0013-GTR19217276-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217276-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR8278 is an REV-ERBα antagonist (EC50 = 0.47 μM) blocking activation of the receptor by the synthetic agonist GSK 4112. (In Vitro) :SR8278 has REV-ERBα transcriptional repression inhibitory activity with an EC50 of 0.47μM. (In Vivo) :SR8278 (slow microinjection; 20 μg/mouse) exerts antidepressant and anxiolytic effects in a circadian time-dependent manner in 6-OHDA-lesioned mice and restores the circadian rhythm of mood-related behaviors.SR8278 (slow microinjection; 20 μg/mouse) restores the binding activities of REV-ERBα and NURR1 to the tyrosine hydroxylase promoter and the induction of enrichment of the R/N motif, recognized by REV-ERBα and NURR1.
CAS Number
1254944-66-5
Purity
>98% (HPLC)
Solubility
DMSO:10mg/ml (27.66mM)
Smiles
CCOC (=O) C1Cc2ccccc2CN1C (=O) c1ccc (SC) s1
Molecular Formula
C18H19NO3S2
Molecular Weight
361.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl 2-{[5- (methylsulfanyl) thiophen-2-yl]carbonyl}-1234-tetrahydroisoquinoline-3-carboxylate

Alternative Products

CatalogName
MBS5758700SR8278
A22100-25SR8278 25mg
A22100-100SR8278 100mg
A22100-5SR8278 5mg
A22100-1SR8278 1mg
A22100-50SR8278 50mg
A22100-10SR8278 10mg
A22100-10mM-DSR8278 10mM * 1mL in DMSO

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