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Pelargonidin chloride

CAT: 0013-GTR19217247-01Size: 100 mgDry Ice: NoHazardous: No
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Description
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.The effect of PC in ameliorating citrinin (CTN) induced cytotoxicity and oxidative stress. The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 μM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 μM. CTN increased lactate dehydrogenase leakage (59%), elevated reactive oxygen species (2.5-fold), depolarized mitochondrial membrane potential as confirmed by JC-1 monomers and arrested cell cycle at G2/M phase. Further, apoptotic and necrotic analysis revealed significant changes followed by DNA damage. To overcome these toxicological effects, PC was pretreated for 2 h followed by CTN exposure for 24 h. Pretreatment with PC resulted in significant increase in cell viability (84.5%), restored membrane integrity, reactive oxygen species level were maintained and cell cycle phases were normal. PC significantly up-regulated the activity of detoxification enzymes: heme oxygenase 1 (HO-1), glutathione transferase, glutathione peroxidase, superoxide dismutase and quinone reductase. Nrf2 translocation into the nucleus was also observed by immunocytochemistry analysis.
CAS Number
134-04-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (326.05 mM)
Smiles
[Cl-].Oc1ccc (cc1) -c1[o+]c2cc (O) cc (O) c2cc1O
Molecular Formula
C15H11ClO5
Molecular Weight
306.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Pelargonidin Chloride

Pelargonidin chloride is an anthocyanidin chloride that has pelargonidin as the cationic counterpart. It has a role as a plant metabolite and a phytoestrogen. It contains a pelargonidin.

CAS Number134-04-3
PubChem CID67249
IUPAC Name2-(4-hydroxyphenyl)chromenylium-3,5,7-triol chloride
Molecular FormulaC15H11ClO5
Molecular Weight306.70
Topological Polar Surface Area81.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity328
SMILES
C1=CC(=CC=C1C2=[O+]C3=CC(=CC(=C3C=C2O)O)O)O.[Cl-]
InChI
InChI=1S/C15H10O5.ClH/c16-9-3-1-8(2-4-9)15-13(19)7-11-12(18)5-10(17)6-14(11)20-15;/h1-7H,(H3-,16,17,18,19);1H
InChIKey
YPVZJXMTXCOTJN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pelargonidin Chloride
CAS: 134-04-3
CID: 67249
Formula: C15H11ClO5
MW: 306.70
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.70
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass306.0295011
Monoisotopic Mass306.0295011
Topological Polar Surface Area81.9 Ų
Heavy Atom Count21
Formal Charge0
Complexity328
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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