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Homoeriodictyol

CAT: 0013-GTR19217239-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217239-01Size:100 mg
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Description
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM. The glucose uptake stimulating effect was sensitive to phloridzin, but not to phloretin, indicating an involvement of the sodium-coupled glucose transporter SGLT-1, but not of sodium-independent glucose transporters (GLUT) . In addition, in contrast to the increased extracellular serotonin levels by stimulation with 500 mM D- (+) -glucose, treatment with 100 μM Homoeriodictyol decreased serotonin release by -48.8 ± 7.57% in Caco-2 cells via a phloridzin-sensitive signaling pathway. Extracellular serotonin levels were also reduced by -57.1 ± 5.43% after application of 0.01 μM Homoeriodictyol to human neural SH-SY5Y cells.
CAS Number
446-71-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (165.41 mM)
Smiles
O=C1C[C@@H] (C2=CC=C (O) C (OC) =C2) OC3=CC (O) =CC (O) =C13
Molecular Formula
C16H14O6
Molecular Weight
302.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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