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P32 Inhibitor M36

CAT: 0013-GTR19217026-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217026-01Size:200 mg
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Description
P32 Inhibitor M36 inhibits SF188 glioma cells proliferation (IC50 of 77.9 μM in complete media) and is much more potent under low glucose conditions with an IC50 of 7.3 μM.p32 Inhibitor M36 is selective for p32 overexpressing cells.p32 Inhibitor M36 is also a potent inhibitor of patient-derived neurospheres with an IC50 of 2.8 μM.
CAS Number
802555-85-7
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 5 mg/mL (11.15 mM)
Molecular Formula
C23H28N8O2
Molecular Weight
448.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

p32 Inhibitor M36
CAS Number802555-85-7
PubChem CID416381
IUPAC Name1-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3-[3-[[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]carbamoylamino]propyl]urea
Molecular FormulaC23H28N8O2
Molecular Weight448.5
XLogP-0.1
Topological Polar Surface Area131
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity680
SMILES
C1CN=C(N1)C2=CC(=CC=C2)NC(=O)NCCCNC(=O)NC3=CC=CC(=C3)C4=NCCN4
InChI
InChI=1S/C23H28N8O2/c32-22(30-18-6-1-4-16(14-18)20-24-10-11-25-20)28-8-3-9-29-23(33)31-19-7-2-5-17(15-19)21-26-12-13-27-21/h1-2,4-7,14-15H,3,8-13H2,(H,24,25)(H,26,27)(H2,28,30,32)(H2,29,31,33)
InChIKey
HHFOXYBNULCICF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of p32 Inhibitor M36
CAS: 802555-85-7
CID: 416381
Formula: C23H28N8O2
MW: 448.5
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight448.5
XLogP3-0.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass448.23352217
Monoisotopic Mass448.23352217
Topological Polar Surface Area131 Ų
Heavy Atom Count33
Formal Charge0
Complexity680
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes