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A 1070722

CAT: 0013-GTR19216985-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216985-01Size:200 mg
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Description
A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α (Ki = 0.6 nM) and GSK-3β (Ki = 0.6 nM) . It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. (In Vivo) :PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain.
CAS Number
1384424-80-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 83.33 mg/mL (230.00 mM)
Smiles
COc1ccc2c (NC (=O) Nc3cccc (n3) C (F) (F) F) ccnc2c1
Molecular Formula
C17H13F3N4O2
Molecular Weight
362.312
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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B7665-50A 1070722
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A19973-10A 1070722 10mg
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