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CB-6644

CAT: 0013-GTR19216959-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19216959-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM) . (In Vitro) :CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. In 123 cell lines such as HCT116, NCI-1975, and HT29 cells, CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM) . (In Vivo) :Administration of oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226, CB-6644 has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.
CAS Number
2316817-88-4
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (174.50 mM)
Smiles
CCOc1cc (F) c (Cl) cc1C (=O) NCC (C) (C) CC (=O) Nc1c (COC) n2CCCc3ccccc3-n2c1=O
Molecular Formula
C29H34ClFN4O5
Molecular Weight
573.06
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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