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ACP-105

CAT: 0013-GTR19216876-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19216876-01Size:1 g
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Description
ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. (In Vitro) :ACP-105 is an SARM with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 in human hepatocytes is 5.0 h. (In Vivo) :Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance.
CAS Number
899821-23-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 103 mg/mL (354.21 mM)
Smiles
Cc1c (Cl) c (ccc1N1[C@H]2CC[C@@H]1C[C@] (C) (O) C2) C#N
Molecular Formula
C16H19ClN2O
Molecular Weight
290.79
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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S0839-5mgACP-105
A-CP-1KG-04ACP 105

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