Hycanthone

Hycanthone is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding (KD: 10 nM) . (In Vitro) :Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Compared to that of controls, results show that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively decreases viral interferon yields as much as 73% . (In Vivo) :Male worms treated with Hycanthone display signs of possible partial recovery from the initial low levels of incorporation. After treatment with Hycanthone, the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease. Immature worms are totally unaffected by Hycanthone at all times tested. In the first four days after treatment, incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50%. 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules .

3105-97-3

Win 249-33 | Etrenol (mesylate)

Pharmacology & Drug Discovery

>98% (HPLC)

In Vitro: DMSO : 12.5 mg/mL (35.07 mM)

CCN (CC) CCNc1ccc (CO) c2sc3ccccc3c (=O) c12

C20H24N2O2S

356.48

Storage temperature: -20°C. Stability: ≥ 2 years