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(R) -Propranolol hydrochloride

CAT: 0013-GTR19216592-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216592-01Size:100 mg
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Description
Dexpropranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. (In Vivo) :Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-) -propranolol is significantly smaller than that of (+) -propranolol ((R) -Propranolol) in both species. Administration of 10 mg/kg (R) -Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation.
CAS Number
13071-11-9
Product Name Alternative
Dexpropranolol hydrochloride | (R) - (+) -Propranolol
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (845.17 mM)
Smiles
Cl.CC (C) NC[C@@H] (O) COc1cccc2ccccc12
Molecular Formula
C16H22ClNO2
Molecular Weight
295.81
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Dexpropranolol Hydrochloride

See also: Dexpropranolol (has active moiety).

CAS Number13071-11-9
PubChem CID66366
IUPAC Name(2R)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride
Molecular FormulaC16H22ClNO2
Molecular Weight295.80
Topological Polar Surface Area41.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count20
Formal Charge0
Complexity257
SMILES
CC(C)NC[C@H](COC1=CC=CC2=CC=CC=C21)O.Cl
InChI
InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m1./s1
InChIKey
ZMRUPTIKESYGQW-PFEQFJNWSA-N
Chemical Structure
2D Structure
2D structure of Dexpropranolol Hydrochloride
CAS: 13071-11-9
CID: 66366
Formula: C16H22ClNO2
MW: 295.80
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight295.80
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass295.1339066
Monoisotopic Mass295.1339066
Topological Polar Surface Area41.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity257
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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