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7-Hydroxycarbostyril

CAT: 0013-GTR19217390-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19217390-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate. (In Vitro) : VPC-80051 as the first small molecule inhibitor of hnRNP A1 splicing activity discovered to date by using a computer-aided drug discovery approach. The inhibitor was developed to target the RNA-binding domain (RBD) of hnRNP A1. Further experimental evaluation demonstrated that VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. This study lays the groundwork for future structure-based development of more potent and selective small molecule inhibitors of hnRNP A1 RNA interactions aimed at altering the production of cancer-specific alternative splice isoforms.
CAS Number
70500-72-0
Product Name Alternative
3,4-Dihydro-7-hydroxycarbostyril
Purity
>98% (HPLC)
Smiles
Oc1ccc2ccc (O) nc2c1
Molecular Formula
C9H7NO2
Molecular Weight
161.16
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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